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Creating pain-sensing neurons

first_imgAfter more than six years of intensive effort, including repeated failures that at times made the quest seem futile, Harvard Stem Cell Institute (HSCI) researchers at Boston Children’s Hospital (BCH) and at Harvard’s Department of Stem Cell and Regenerative Biology (HSCRB) have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory distress.This “disease in a dish” model of pain reception may advance the understanding of different types of pain, identify why individuals differ in their pain responses or their risk of developing chronic pain, and make possible the development of improved drugs to treat pain. A report on the work was given advance online release today by the journal Nature Neuroscience.Clifford Woolf, co-director of HSCI’s Nervous System Diseases Program, led the research effort. Postdoctoral fellows Brian Wainger and Liz Buttermore are first authors on the journal paper. Woolf’s collaborators on the project included Lee Rubin and Kevin Eggan, both professors in HSCRB.The neuronal pain receptors created by Woolf and his team reportedly respond to both the kind of intense stimuli that are triggered by a physical injury and that cause “ouch” pain, and the more subtle stimuli triggered by inflammation, which results in pain tenderness. The fact that the neurons respond to both the gross and fine forms of stimulation that produce distinct pain in humans provides confirmation that the neurons are functioning as naturally developed neurons would, Woolf said.When the project began, Woolf’s team was attempting to create pain-sensing neurons from embryonic stem cells, but the task proved far more challenging than first envisioned.“We spent three years trying to recapitulate the developmental steps involved, and it turned out to be a total bust,” said Woolf, who in addition to his HSCI roles is a Harvard Medical School (HMS) professor of neurology and neurobiology, and director of the F.M. Kirby Neurobiology Center at BCH. But the effort to develop pain-sensing neurons was occurring at just the right moment in the evolution of stem cell biology, coinciding with the development of induced pluripotent stem cell (iPS) technology, the ability to transform adult human cells into stem cells and then into other forms of adult cells.The project was the original effort of an ongoing collaboration between HSCI researchers and pharmaceutical giant GlaxoSmithKline, and, said Woolf, “for the first three years it was a total bust. But they, like us, were in it for the long haul.”Describing the early days of the project as “hitting our head against a brick wall,” Woolf said that “we had a dogged kind of persistence,” and once the team began attempting to create the neurons directly from mouse and human skin cells, everything began to fall into place.“We took mature neurons from mice, and found transcription factors that hadn’t been described before,” Woolf said. Then, using five factors — including three previously undescribed factors — the team was able to transform skin cells directly into the pain-sensing neurons.Asked what kept him pushing through repeated failures to make pain neurons using different approaches, initially starting with human embryonic stem cells, Woolf said, “It’s really complicated, because there are many projects I do pull the plug on, when I can’t see any way out of it. Here, even though we experienced failure constantly, I always felt there was something else we could do that would advance the work. Whether it was worth this long haul, time will tell. I’m optimistic.“I think the ability to make human pain neurons for the pain field is going to be very important. Furthermore, our failure with embryonic stem cells led us to work with adult tissue samples, making the technology much more clinically relevant, since these are easy to collect [from patients suffering from different kinds of pain],” he added.Woolf noted that the pain-sensing neurons his team developed “beautifully model” neuropathies and hypersensitivity to pain experienced by some of the patients who donated skin cells to the project. “Many pain conditions are due to genetic mutations, and we can model those beautifully,” Woolf said.last_img read more

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What does Malcolm X have to do with credit unions turning millennials into members?

first_img 2SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr by: David GilbertWell, nothing, at least on a personal level. But consider a line the influential activist issued during a 1963 speech that some of you children of the ’80s might more easily recognize as the opening salvo of the radio hit “Cult of Personality” by the band Living Colour;“And during the few moments that we have left … we want to talk right down to earth in a language that everybody here can easily understand.”Notably, that speech — recognized by scholars as one of the best of the 20th century — was titled, “Message to the Grass Roots.”For millennials, from a marketing perspective, that easily understandable, grass-roots language is social media. Nearly three-quarters of young adults ages 18 through 35 use social media daily. Meanwhile, they’re tuning out traditional advertising. According to a detailed survey by Elite Daily, a popular Gen Y online news platform, just 1% of millennials said a compelling ad would make them trust a brand more. continue reading »last_img read more

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Rumble in the urban jungle

first_imgWould you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletters To access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week.last_img

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Himamaylan City launches ‘Bike to Work, Bike to School’ program

first_img“We want to have bike lanes that are functional, safe and free from obstacles and hazard,” she added. She added that the City Council headed by Vice Mayor Justin Gatuslao will pass a resolution encouraging residents to use bicycles as an alternative form of transportation. City environment management officer-designate Armela Waldato, for her part, said the launched activity serves as a prelude to a “bigger plan” to establish bike lanes in the major roads of Himamaylan. According to Waldato, bicycles as alternative mode of transportation will help save the environment by cutting down carbon footprint. Various members of various bikers clubs, volunteers and government personnel attend the kickoff of the 16th Environment Week held at the city hall of Himamaylan, Negros Occidental on June 9. During the event, the city government launched the “Bike to Work and Bike to School” program as part of its efforts to protect Mother Nature. MAYOR RAYMUND I. TONGSON FB PAGE The opening program of the 16th Environment Week was attended by members of various bikers club, Bantay Bukid volunteers and personnel of the Department of Environment and Natural Resources and Provincial Environment Management Office. In November last year, Himamaylan hosted the 5th Tour of the Fireflies which was participated by some 4,000 bikers.(With a report from PNA/PN) Mayor Raymund Tongson, who led the launching activity, said going back to the basics like using a bicycle to go to school or work is one way for the Himamaylanons to “secure the community and protect the environment”. “We are going back to basics. Through biking, we are able to appreciate the simplest things around us. Our thrust is defending and securing the simplest things in our community today,” he added. The mayors said on his Facebook post that he hopes that people will realize Mother Nature is healing while communities have been quarantined for months and socio-economic movements have been challenged due to coronavirus disease 2019 outbreak. BACOLOD City – The “Bike to Work and Bike to School” program has been introduced by the local government of Himamaylan City, Negros Occidental as part of its efforts to protect the environment. The initiative was launched during the kickoff of the 16th Environment Week with a theme “Time for Nature” held at the city hall on June 9.last_img read more

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Girls Area Tennis Sectionals Scores

first_imgArea Girls Tennis Sectionals Scores.Wednesday (5-18) @ South Dearborn.East Central  3     Lawrenceburg  2South Dearborn  5     Milan  0Wednesday (5-18) @ Connersville.Franklin County  3     Rushville  2Union County  3     Connersville  2Wednesday (5-18) @ Greensburg.Jennings County  3     Greensburg  2last_img

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What’s Wrong With NASCAR?

first_imgEven though the start of the NASCAR season has had different winners each week, attendance is still down.  This continues a trend that has occurred  the last several seasons.  NASCAR officials hoped that their 3-phase races this season would put crowds back in the seats.  So far, it has not.This year each race is divided into 3 sections and points are awarded to the top 10 finishers in each segment.  Of course, the last segment is the winning segment so more points are awarded then.  This was to keep people guessing as to who could accumulate the most points each week.  Too often in the past, a couple of drivers have dominated the season and the officials thought that was the reason attendance was down.I think the major reason for poorer attendance is the lack of big names.  We no longer have Dale Earnhardt, Sr., Richard Petty, or Jeff Gordon to bring the fans into the stands.  Also, NASCAR fans tend to be middle class factory-type workers, and thus, the closing of many factories that this group of people worked in means less money to spend on entertainment.  We will have to see if NASCAR can attract a broader range of fans.last_img read more

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Other Sports Sameer Verma loses to Shi Yuqi in the Malaysia Open Badminton tournament

first_imgThe second game was no different as the Indian was lagging 11-16 again but this time he not only clawed back at 20-20. And even though the Chinese had grabbed one match point, Sameer reeled off three points to take the match to the decider. In the third game, Shi Yuqi jumped to a 9-0 lead and didn’t allow the Indian to fight back.   For all the Latest Sports News News, Other Sports News, Download News Nation Android and iOS Mobile Apps. Pranaav Jerry Chopra and N Sikki Reddy made a good start.Shi Yuqi is the world number-two ranked player.Verma had lost to Shi Yuqi in the semifinals of the World Tour Finals. highlights Kuala Lumpur: India’s Sameer Verma put up a daunting effort before going down in three games in a pulsating opening round clash against World no 2 Chinese Shi Yuqi in the USD 750,000 Malaysia Open in Kuala Lumpur on Tuesday. The 24-year-old from Madhya Pradesh, who had lost to Shi Yuqi in the semifinals of the World Tour Finals in December last year, suffered a heart-breaking 20-22 23-21 12-21 loss in a 65-minute men’s singles in Kuala Lumpur on Tuesday. Pranaav Jerry Chopra and N Sikki Reddy, however, made a good start to their campaign, eking out a 22-20 24-22 win over Ireland’s Sam Magee and Chloe Magee in mixed doubles. The men’s singles match was a close battle till 8-8, Sameer fall back to 11-16 but he fought back to make it 20-20 before being edged out by Shi Yuqi in the opening game.last_img read more

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The Latest: England could cut short women’s soccer season

first_img Share This StoryFacebookTwitteremailPrintLinkedinRedditThe Latest on the effects of the coronavirus outbreak on sports around the world:___The English Football Association says it is in discussion with clubs in the top women’s league about the possibility of cutting short the season because of the coronavirus pandemic. ___A soccer player in Germany for third-division club Chemnitz has tested positive for the coronavirus.Chemnitz did not name the player but the club says he is “completely symptom-free.” That player and two other players who had contact with him will spend 14 days in isolation.Chemnitz says the player tested positive in a sample taken Saturday but had tested negative in a sample from two days before that. The club says it can still return to full team training on Tuesday.The first and second divisions in Germany returned to play Saturday but the third-division restart was postponed last week from its planned date of May 26. Some clubs have still not received clearance from local authorities to play or hold full training sessions. Associated Press The FA says there are “significant challenges” in completing the season and the governing body is seeking views on the “most appropriate sporting outcome.”Manchester City leads the Women’s Super League by one point. Chelsea is second and has played one game fewer.No league games have been played since February.___UEFA says it has postponed an executive committee meeting by three weeks because of issues regarding the venues for the rescheduled European Championship in 2021. The Scottish Professional Football League says clubs expressed a unanimous view that there is no prospect of completing the season.The SPFL says it has accepted their decision and is now able to pay out $8.5 million in fees “to help clubs stay afloat.”There have been no games in the Scottish Premiership since March 13 because of the pandemic. Final season placings have been determined by points per game up to that point.Celtic had 80 points from 30 games so has 2.66 points per game. Rangers finished second with 2.31 points per game.Hearts has been relegated. The 26-year-old Spaniard had said it didn’t make sense to play soccer while people were dying because of the virus. He said he would not forgive himself if he got infected and passed the virus to a family member.Cádiz lauded Giménez’s return and published photos and videos of him training with his teammates. He underwent alternative drills because he missed last week’s sessions.___Celtic has been declared Scottish champion after the country’s top soccer league was cut short because of the coronavirus outbreak.It is Celtic’s ninth straight title. ___Soccer players in Italy will have to wait at least another 24 hours before restarting full team training.Italian clubs resumed training on an individual basis on May 4 when lockdown measures in the country started to ease. They were slated to return to training together on Monday but they have not yet been given the green light to do so by the Italian government’s scientific panel.The medical protocol for the resumption of Serie A has proved contentious but a revised document was delivered to Sports Minister Vincenzo Spadafora on Sunday and is expected to be given to the scientific panel on Monday.Serie A plans to resume on June 13. ___Belgian soccer clubs have been allowed the possibility to designate three teams they don’t want to host in empty stadiums next season.The league says it will try to accommodate the club’s wishes amid the coronavirus pandemic.The measure could be used by clubs to avoid playing famous clubs or bitter rivals in front of empty stands for matches that usually draw many fans and generate big ticketing revenue.All sporting competitions in Belgium will remain suspended until July 31 because of the health situation and all mass events have been banned until Aug. 31. The first round of soccer matches for next season will likely be played without fans when the league resumes on Aug. 7.center_img The Latest: England could cut short women’s soccer season May 18, 2020 Club Brugge was awarded its 16th Belgian title last week after the league announced the end of the season with the current standings declared final.___The Spanish soccer player who threatened to quit his team rather than risk being infected by the coronavirus has returned to training.Cádiz defender Fali Giménez rejoined his teammates at the second-division club about a month after saying he wouldn’t play again unless there was a vaccine for COVID-19 or if he was assured 100% that he wouldn’t get infected after being back on the field.Giménez did not practice last week as the rest of the squad returned to training nearly two months after soccer was halted. The 24-team tournament was pushed back a year because of the coronavirus pandemic. It is scheduled to use 12 stadiums in 12 nations.UEFA wanted the host cities to confirm they could still stage games.The governing body of European soccer says its executive committee will meet on June 17 instead of May 27 “due to the existence of some remaining open points regarding a small number of proposed venues” for Euro 2020.UEFA president Aleksander Ceferin has said Euro 2020 can be staged without all 12 stadiums.___ ___More AP sports: https://apnews.com/apf-sports and https://twitter.com/AP_Sports,Tampa Bay Lightning advance to face Dallas Stars in Stanley Cup finals, beating New York Islanders 2-1 in OT in Game 6 Premier League clubs have agreed on the measures that will allow non-contact training sessions to resume this week amid the coronavirus pandemic.The protocols for socially distanced training in small groups were signed off by the clubs during a conference call following a government decision to ease lockdown restrictions in England.Contact training and matches have yet to be allowed by the government.The Premier League season was suspended in March with Liverpool leading by 25 points with nine games remaining.Coronavirus testing is due to take place twice each week at clubs on up to 40 players, coaches and support staff.last_img read more

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No. 12 baseball opens season with three weekend games

first_imgNo. 12 USC baseball opens its season against North Dakota at Dedeaux Field on Friday where the Trojans look to forget their disappointing loss in extra-innings to Virginia in last year’s NCAA Regional Final. Although the team’s trip to Lake Elsinore in 2015 didn’t end the way head coach Dan Hubbs had planned, he hoped his players would take confidence from their postseason experience and bring it into the new year.“Virginia were the eventual national champions,” Hubbs said. “And the team that they beat [in the College World Series Finals], Vanderbilt, we beat earlier in the year. Another team, TCU, went [to the World Series], and we beat them, too.”Hubbs also said the key to having a good season, starting this weekend against the Fighting Hawks, was to “maintain that edge” that the squad’s returning members earned through their experience last season.“The makeup on the team is strong. I think the makeup of the team is great,” Hubbs said. “We have a ton of guys back from last year’s team who know what it takes, and the leadership is strong.”Senior pitcher Kyle Davis is one of 20 returners to the Trojan roster this year, and he is scheduled to toe the rubber as the starter for Friday’s opener. The veteran hurler, who was selected by the Toronto Blue Jays in the 29th round of last summer’s MLB draft, was itching to get back on the mound in a non-intrasquad game.“It’ll be nice to finally face another team other than ourselves,” Davis said. “Getting out there again and pitching on opening day will be cool for me.”Junior Jeremy Martinez, who will be called on to fill the backstop void left by graduated Johnny Bench Award winner Garrett Stubbs this year, agreed.“It’s going to be nice to put on a uniform again, to see fans in the stadium and all that good stuff we like playing baseball for,” Martinez said. “If we play our type of baseball, we’re going to come out on top with a three-game sweep.”After spending most of 2015 at first base, Martinez will catch and call the games for Davis and the rest of the pitching staff against an unfamiliar foe in North Dakota. The Fighting Hawks compete in the Western Athletic Conference against the likes of Cal State Bakersfield and Seattle University.The last time the Trojans played anyone from the conference was in 2014, when they beat Grand Canyon, 6-3, at home. North Dakota finished last season with a 24-27 overall record. The Fighting Hawks entered the WAC Tournament as the No. 3 seed and managed to beat Northern Colorado, but successive losses to Bakersfield and Sacramento State denied them a conference championship.Regardless of opponent, Martinez said the team is looking forward to starting the season.“[We want] to just go out there and have fun, not put too much pressure on ourselves and enjoy the moment,” Martinez said.But when asked about their ambitions for the season as a whole, both Martinez and Davis have very clear goals in mind.“It’s national championship or bust,” Martinez said.Davis agreed with Martinez.“Especially coming off of last year,” Davis said. “Being so experienced this year, it’ll be Omaha, the World Series.”First pitch on opening day is scheduled for 6 p.m. on Friday at Dedeaux Field. Saturday’s game begins at 2 p.m., and the Trojans will wrap up their three-game set against North Dakota on Sunday at 1 p.m.last_img read more

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At the Races pens exclusive Hong Kong racing rights deal

first_img StumbleUpon At The Races (ATR) and Sky Sports Racing are to be the new exclusive, non-terrestrial, broadcast home of Hong Kong racing in the United Kingdom and Ireland until July 2022, it has been revealed today.Revealed by ATR and The Hong Kong Jockey Club (HKJC), who have overseen racing in the territory since 1984, it’s to see a record £120m ($HK 1.2 billion) in prize money featured as part of the 2018/19 season.Broadcast across the UK and Ireland is to take place on At The Races until the end of this year, before taken over by its successor channel Sky Sports Racing, which is to launch in full HD on or before January 1st, 2019, becoming the eleventh Sky Sports channel.George Irvine, Commingling Development Director at the HKJC, explained: “Sky Sports is recognised globally as a benchmark in sports broadcast and innovation. This new partnership aligns with The Hong Kong Jockey Club’s deep-rooted values in world-class leadership and continuous development.“We want to continue to engage UK and Ireland audiences in our premium racing product. ATR and Sky Sports have significant fan bases already across TV and digital channels, and we will work with them not just on live race coverage but on a weekly, dedicated preview programme to showcase Hong Kong racing.”The HKJC boasts some of the world’s most prestigious thoroughbred races, and one of the largest pool betting operations with annual turnover of £11.9bn ($HK 124.2bn).The Longines Hong Kong Cup (2000m), worth HK$28m (£2.8m), is one of the two richest races in the world at a mile and a quarter on turf. The Longines Hong Kong Mile (1600m) and Longines Hong Kong Sprint (1200m) are the most lucrative Group 1 turf races in the world over their distances, worth HK$25m (£2.5m) and HK$20m (£2m) respectively.Matthew Imi, Chief Executive of At The Races, added: “The Longines Hong Kong International Race is one of the world’s greatest racing fixtures. We are delighted to partner with the Hong Kong Jockey Club to deliver ground breaking coverage of this spectacular event, and to promote consistently throughout the rest of the season the high-quality racing that the club supports.” Share Submit Share UK racing remains hopeful for crowd pilot events August 14, 2020 Related Articles Ascot adds three-year extension to Sky Sports Racing deal August 14, 2020 HKJC closes OCBBs amid rising public health concerns July 13, 2020last_img read more

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